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Insulin-like growth factors and liver cancer risk in male smokers

✍ Scribed by Major, J M; Stolzenberg-Solomon, R Z; Pollak, M N; Snyder, K; Virtamo, J; Albanes, D

Book ID: 110000629
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 185 KB
Volume: 103
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6605842

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Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions