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Insulin-like growth factor I/somatomedin-C (IGF-I/SM-C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts

✍ Scribed by Cheryl A. Conover; Laura A. Dollar; Raymond L. Hintz; Ron G. Rosenfeld

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 739 KB
Volume: 116
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041160210

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✦ Synopsis

In serum-free medium, insulin-like growth factor-lisomatomedin-C (IGWSM-C) was weakly mitogenic for adult human fibroblasts in culture. However, in the presence of 0.5% h u m a n hypopituitary serum (HHS), which by itself had little effect, there was a marked dose-dependent response to IGF-IISM-C with a 10-to 20-fold increase in [3H]thymidine incorporation at 25 ngIml IFG-I/SM-C. With the further addition of dexamethasone or hydrocortisone to t h e

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Hormonal control of the replication of human fetal fibroblasts: Role of somatomedin C/insulin-like growth factor I

✍ Cheryl A. Conover; Ron G. Rosenfeld; Raymond L. Hintz 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 945 KB

Sparse cultures of fetal and postnatal human fibroblasts were equivalent in their responsiveness to the mitogenic action of somatomedin C/insulin-like growth factor I (SM-C/IGF-I). At both developmental stages, the addition of SM-C/IGF-I (100 ng/ml) increased cell number at day 3 1.4-fold in serum-f