Alternate signaling pathways selectively
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Thomas L. Mccarthy; Changhua Ji; Sandra Casinghino; Michael Centrella
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Article
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1998
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John Wiley and Sons
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English
โ 170 KB
๐ 2 views
Bone cells synthesize and respond to IGF-I and IGF-II which contribute to bone remodeling and linear growth. In osteoblasts, prostaglandin (PG)E 2 stimulates IGF-I but not IGF-II synthesis through a cAMP-dependent protein kinase A (PKA)-related event. However, protein kinase C (PKC) activation by PG