The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-I, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinoblastoma, colon carcinoma, liver adenocarcinoma, Burk
Insulin-like growth factor II in two human colon-carcinoma cell lines: Gene structure and expression, and protein secretion
β Scribed by Sylvie Lambert; Agnes Carlisi; Julien Collette; Paul Franchimont; Rosita Gol-Winkler
- Book ID
- 118283980
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 855 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0020-7136
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## Abstract The HTβ29 human colon cancer cell line has previously been shown to secrete high amounts of insulinβlike growth factor II (IGFβII). The recent demonstration that soluble IGFβII/ mannose 6βphosphate receptor was present in fetal serum prompted us to search for a release of typeβII IGF re
We investigated expression of insulin-like growth factor II (Igf2) in primary cultured hepatocytes, liver epithelial (LE) cell lines derived from normal hepatocytes, and hepatocellular carcinoma (HCC) cell lines from crosses between C3H/HeJ (C3H) and Mus musculus molossinus mice (MSM). Igf2 mRNA was