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Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression

✍ Scribed by Elizabeth A. Beierle; Louise F. Strande; Mike K. Chen


Book ID
117827433
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
71 KB
Volume
37
Category
Article
ISSN
0022-3468

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Neuroblastoma is a childhood tumor of the peripheral nervous system that remains largely uncurable by conventional methods. Mannitol induces apoptosis in neuroblastoma cell types and insulin-like growth factor I (IGF-I) protects these cells from hyperosmotic-induced apoptosis by affecting apoptosis-