Insulin-like growth factor I is the key
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Cynthia M. Van Golen; Eva L. Feldman
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Article
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2000
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John Wiley and Sons
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English
β 249 KB
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Neuroblastoma is a childhood tumor of the peripheral nervous system that remains largely uncurable by conventional methods. Mannitol induces apoptosis in neuroblastoma cell types and insulin-like growth factor I (IGF-I) protects these cells from hyperosmotic-induced apoptosis by affecting apoptosis-