Insulin-like growth factor I partly prevents axon elimination in the neonate rat optic nerve
✍ Scribed by Gabriel Gutiérrez-Ospina; Andrea Gutiérrez de la Barrera; Jorge Larriva; Magda Giordano
- Book ID
- 117472753
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 199 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0304-3940
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## Abstract The in vivo actions of insulin‐like growth factor I (IGF‐I) on synaptogenesis in the hypoglossal nucleus were investigated in transgenic mice that overexpress IGF‐I in the brain postnatally and in normal nontransgenic littermate controls. In a previous study using these mice, we found t
Insulin-like growth factor-I (IGF-I) promotes axonal regeneration in the peripheral nervous system and this effect is enhanced by platelet-derived growth factor (PDGF). We decided, therefore, to study the effects of these factors on axonal regeneration in the adult rat spinal cord. Semipermeable pol