Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells
β Scribed by C.C Matthews; H.M Odeh; E.L Feldman
- Book ID
- 117491681
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 323 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0306-4522
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## Abstract The insulinβlike growth factor (IGF) system is a key regulator of cell growth, survival and differentiation, and these functions are coβmodulated by other growth factors including fibroblast growth factorβ2 (FGFβ2). To investigate IGF/FGF interactions in neuronal cells, we employed neur
Neuroblastoma is a childhood tumor of the peripheral nervous system that remains largely uncurable by conventional methods. Mannitol induces apoptosis in neuroblastoma cell types and insulin-like growth factor I (IGF-I) protects these cells from hyperosmotic-induced apoptosis by affecting apoptosis-