Insulin-like growth factor-I and the liver
✍ Scribed by Karen Bonefeld; Søren Møller
- Book ID
- 111239450
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 278 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0106-9543
No coin nor oath required. For personal study only.
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## Abstract Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and tyrosine kinase growth factor signaling. We have recently demonstrated that PTP1B deficiency increases GLUT2/insulin receptor (IR) A complexes and glucose uptake in suckling, but not adult, primary hepatocyte
The insulin-like growth factor binding protein-1 (IGFBP-1) gene is highly expressed in fetal, perinatal, and regenerating liver. Up-regulation is transcriptionally mediated in regenerating liver and occurs in the first few minutes to hours after partial hepatectomy. In transgenic mice a 970-bp regio