Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy
✍ Scribed by Davison, Zoë; de Blacquière, Gail E.; Westley, Bruce R.; May, Felicity E.B.
- Book ID
- 122309452
- Publisher
- Neoplasia Press
- Year
- 2011
- Tongue
- English
- Weight
- 905 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1522-8002
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Tumor recurrence is a common problem in the treatment of breast cancer. In breast cancer, the expression of high protein levels of the insulin-like growth factor-1 receptor (IGF-1R) and urokinase-type plasminogen activator-1 (uPA) is strongly associated with breast cancer recurrence and decreased su
## Abstract The insulin‐like growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBP‐1 purified from human amniotic fluid neutralizes IGF‐I‐dependent growth of MCF‐7 cells. In thi