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Insulin-Like Growth Factor Binding Proteins: IGF-Dependent and -Independent Effects in the Mammary Gland

✍ Scribed by David J. Flint; Elizabeth Tonner; Gordon J. Allan


Book ID
110275466
Publisher
Springer US
Year
2000
Tongue
English
Weight
78 KB
Volume
5
Category
Article
ISSN
1083-3021

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Insulin-like growth factor binding prote
✍ Constance J. Grill; Wendie S. Cohick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 215 KB πŸ‘ 2 views

IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect