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Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes

✍ Scribed by Daniel Chesik; Jacques De Keyser; Reinier Bron; Gwenny M. Fuhler


Book ID
111183969
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
768 KB
Volume
113
Category
Article
ISSN
0022-3042

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Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. A