Insulin-like growth factor action and skeletal muscle growth, an in vivo perspective
β Scribed by Peter Rotwein
- Book ID
- 116511933
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 150 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1096-6374
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Insulin-like growth factor (IGF) I, a polypeptide synthesized by skeletal cells, is presumed to act as an autocrine regulator of bone formation. IGF I stimulates bone replication of preosteoblastic cells and enhances the differentiated function of the osteoblast. The synthesis of skeletal IGF I is r
The acute metabolic actions of insulin-like growth factor I were studied in anaesthetized adult rats and its potency was compared to that of insulin. Following an i.v. bolus injection of insulin-like growth factor I a dose-dependent decrease of blood glucose and serum non-esterified fatty acid conce