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Insulin-like growth-factor-1-induced PKB signaling and Egr-1 expression is inhibited by curcumin in A-10 vascular smooth muscle cells 1

✍ Scribed by Youreva, Viktoria; Kapakos, Georgia; Srivastava, Ashok K.

Book ID: 120077622
Publisher: NRC Research Press
Year: 2013
Tongue: French
Weight: 666 KB
Volume: 91
Category: Article
ISSN: 0008-4212
DOI: 10.1139/cjpp-2012-0267

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## Abstract Advanced age is a major risk factor for atherosclerosis, but how aging per se influences pathogenesis is not clear. Insulin‐like growth factor‐1 receptor (IGF‐1R) promotes aortic vascular smooth muscle cell (VSMC) growth, migration, and extracellular matrix formation, but how IGF‐1R sig