The insulin-like growth factor 2 (IGF2) gene is regulated in a complex manner, involving developmentally regulated use of four different promoters as well as transcriptional repression of the maternal allele due to genomic imprinting. It has been well documented that liver is an exceptional organ in
Insulin-like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men
โ Scribed by Sherri O. Stuver; Hannah Kuper; Anastasia Tzonou; Pagona Lagiou; Evangelos Spanos; Chung-Cheng Hsieh; Christos Mantzoros; Dimitrios Trichopoulos
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 55 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0020-7136
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We investigated expression of insulin-like growth factor II (Igf2) in primary cultured hepatocytes, liver epithelial (LE) cell lines derived from normal hepatocytes, and hepatocellular carcinoma (HCC) cell lines from crosses between C3H/HeJ (C3H) and Mus musculus molossinus mice (MSM). Igf2 mRNA was
Insulin-like growth factor 2 (IGF2) gene imprinting has been demonstrated to be promoter-specific, in that expression from the P1 promoter is biallelic whereas that from the P2-P4 promoters is monoallelic. In the present study, in order to investigate IGF2 gene imprinting status at the cellular leve