Insulin-like growth factor-1 boosts the developing process of condylar hyperplasia by stimulating chondrocytes proliferation
β Scribed by Y. Chen; J. Ke; X. Long; Q. Meng; M. Deng; W. Fang; J. Li; H. Cai; S. Chen
- Book ID
- 113733418
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 783 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1063-4584
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Using monolayer cultures of costal chondrocytes established from four week old Clun Forest lambs, we have demonstrated that, under serum free conditions the cells release three IGFBPs (32, 29 and 21 kDa) into the medium. The most abundant of these--the 32 kDa BP--was shown to be IGFBP-2 by Western b
## Abstract Interleukinβ1 (ILβ1) and insulinβlike growth factorβI (IGFβI), which have opposing effects on matrix metabolism within articular cartilage, are thought to play prominent roles in the pathogenesis of osteoarthritis. To better understand the link between these anabolic (IGFβI) and catabol