A sensitive RIA was used to examine regulation of IGFBP-1 in H411E rat hepatoma cells. IGFBP-1 was stimulated up to tenfold by dexamethasone and corticosterone, and this stimulation was abolished by RU486. The effect of dexamethasone increased with time in culture. Phorbol 12-myristate 13-acetate (P
โฆ LIBER โฆ
Insulin-like growth factor 1 and insulin reduce epidermal growth factor binding to Swiss 3T3 cells by an indirect mechanism that is apparently independent of protein kinase C
โ Scribed by Anthony N. Corps; Kenneth D. Brown
- Book ID
- 115920583
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 377 KB
- Volume
- 233
- Category
- Article
- ISSN
- 0014-5793
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Swiss 3T3 mouse fibroblasts were exposed to 10 microM colchicine to disrupt microtubules, then stimulated with insulin-like growth factor-I. Immunoprecipitation experiments showed that insulin-like growth factor-I receptor and insulin receptor substrate-1 were tyrosine phosphorylated to the same ext