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Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

✍ Scribed by M Lesort; G.V.W Johnson

Book ID: 117489742
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 666 KB
Volume: 99
Category: Article
ISSN: 0306-4522
DOI: 10.1016/s0306-4522(00)00200-1

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## Abstract Survival signals such as insulin‐like growth factor‐1 (IGF‐1) or membrane depolarization convey their neuronal protective effects through the activation of signaling networks and nuclear factors. In cerebellar granule neurons, IGF‐1 mediates survival primarily through the PI3K/Akt pathw