To examine the existence of negative cooperativity among formyl peptide chemotaxis receptors, steady-state binding off Met-Le~-[~H]Phe to viable rat neutrophils and their purified plasma membranes was measured and the data were subjected to statistical analysis and to computer curve fitting using th
β¦ LIBER β¦
Insulin interactions with its receptors: Experimental evidence for negative cooperativity
β Scribed by Pierre De Meyts; Jesse Roth; David M. Neville Jr; James R. Gavin III; Maxine A. Lesniak
- Book ID
- 119405314
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 384 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0006-291X
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The human insulin analogue ASPB 10 has been reported to have increased affinity for the insulin receptor and to cause breast cancer in female rats. In the study reported here, we investigated whether ASPB 10 has an increased mitogenic potency and induces a transformed phenotype in cultured human bre