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Insulin increases distinct species of 1,2-diacylglycerol in isolated perfused rat heart

โœ Scribed by Kenji Okumura; Hideo Matsui; Kichiro Murase; Akemi Shimauchi; Kiyokazu Shimizu; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa

Book ID
117180085
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
758 KB
Volume
45
Category
Article
ISSN
1532-8600

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Phosphoinositide hydrolysis is elicited by alpha-adrenoceptor stimulation in the myocardium, resulting in the generation of 1,2-diacylglycerol by the direct activation of phospholipase C. However, the physiological role of 1,2-diacylglycerol accumulation in the heart has been largely unexplored. The