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Insulin glargine is more potent in activating the human IGF-I receptor than human insulin and insulin detemir

✍ Scribed by A.J. Varewijck; J.A. Goudzwaard; M.P. Brugts; S.W.J. Lamberts; L.J. Hofland; J.A.M.J.L. Janssen

Book ID: 116512389
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 414 KB
Volume: 20
Category: Article
ISSN: 1096-6374
DOI: 10.1016/j.ghir.2010.10.002

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## Abstract We studied expression and functional characteristics of the insulin‐ and insulin‐like‐growth‐factor‐1(IGF‐1) receptors in human renal carcinoma. Ligand‐binding properties and tyrosine‐kinase activity of both receptors, as well as the expression of the 2 isoforms of the human insulin rec