Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart

✍ Scribed by M. A. Nerurkar; J. G. Satav; S. S. Katyare

• Publisher: Springer
• Year: 1988
• Tongue: English
• Weight: 422 KB
• Volume: 31
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00395559

✦ Synopsis

Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.