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Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells

✍ Scribed by Wenwu Gao; Patricia B. Eisenhauer; Kelly Conn; John A. Lynch; John M. Wells; M. David Ullman; Ann McKee; Hamant S. Thatte; Richard E. Fine


Book ID
116767016
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
280 KB
Volume
371
Category
Article
ISSN
0304-3940

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## Abstract Insulin degrading enzyme (IDE) is expressed in the brain and may play an important role there in the degradation of the amyloid beta peptide (AΞ²). Our results show that cultured human cerebrovascular endothelial cells (HCECs), a primary component of the blood–brain barrier, express IDE