✦ LIBER ✦

Insulin binding in denervated muscle

✍ Scribed by Dr. Deirdre Donaldson; Dr. Owen B. Evans; Dr. Robert W. Harrison

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 407 KB
Volume: 9
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880090304

No coin nor oath required. For personal study only.

✦ Synopsis

Insulin binding was measured in rat muscle following denervation. There was a 40% reduction in the number of high-affinity insulin receptors, with no change in the insulin binding Kd. Selected muscles showed a 40%-60% reduction in weight during this period. The downregulation in the number of insulin receptors may contribute to the mechanism of muscle atrophy following denervation.

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