Insulin binding and insulin action in rat fat cells after adrenalectomy
✍ Scribed by H. Häring; C. Calle; A. Bug; R. Renner; K. D. Hepp; W. Kemmler
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 667 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0012-186X
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Insulin resistance was studied by comparing insulin response and insulin binding in four groups of rats. Glucose metabolism in isolated fat cells from male Wistar rats weighing 340 g was less responsive to a supramaximal dose of insulin than glucose metabolism in fat cells from rats weighing 200 g.
The effects of chronic elevations of growth hormone levels on hepatic insulin binding and action were studied in rats with subcutaneously implanted growth hormone-producing tumours. These animals were significantly heavier (p less than 0.001; 388 +/- 29 versus 239 +/- 4 g), had elevated insulin leve