✦ LIBER ✦

Insulin and somatemedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

✍ Scribed by Mark Bothwell

Book ID: 102383834
Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 431 KB
Volume: 8
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490080212

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✦ Synopsis

Abstract

Sensory neurons isolated from 8‐day chick embryo dorsal root ganglia are shown to be capable of surviving in tissue culture and extending neurites in the absence of nerve growth factor. Survival and formation of neurites by cells cultured in medium supplemented with 2% fetal calf serum is stimulated by insulin, proinsulin or somatemedin MSA. MSA is effective at much lower concentrations (50 ng/ml) than insulin or proinsulin and is suggested to be a physiological regulator of sensory neuronal development. It is demonstrated that at least part of the neuronal population is responsive to both nerve growth factor and insulin homologs.

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