๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Insular Thyroid Carcinoma in a Patient with Cowden Syndrome

โœ Scribed by Henry R. Diggelmann; Douglas J. Van; Thomas M. O'Dorisio; Henry T. Hoffman

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
427 KB
Volume
119
Category
Article
ISSN
0023-852X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Cowden syndrome is characterized hamartomatous lesions that can develop from all three germ cell derivatives. This disorder predisposes patients to develop malignant tumors of the breast, endometrium, and thyroid. We present a patient with clinically relevant manifestations of Cowden syndrome, with genetic verification, impacting by way of airway compromise due to hamartomas, urinary tract abnormalities, and insular thyroid cancer. This case illustrates the value of recognizing Cowden syndrome at an earlier stage to (1) permit early management to decrease the morbidity of untreated hamartomatous growths, and (2) perform an elective thyroidectomy to preempt the appearance of the thyroid malignancy. Through this case report, we provide further insight into management of this disorder.

๐Ÿ“œ SIMILAR VOLUMES

Insular thyroid carcinoma in a patient w
Insular thyroid carcinoma in a patient with Cowden syndrome
โœ Henry R. Diggelmann; Douglas J. Van Daele; Thomas M. O'Dorisio; Henry T. Hoffman ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 159 KB

## Abstract Cowden syndrome is an autosomal dominant disorder characterized by benign and malignant hamartomatous lesions that can develop from all three germ cell derivatives. This disorder predisposes patients to develop malignant tumors of the breast, endometrium, and thyroid. We present a patie

Thyroid carcinomas with a variable insul
Thyroid carcinomas with a variable insular component : Prognostic significance of histopathologic patterns
โœ Vittoria Rufini; Massimo Salvatori; Guido Fadda; Luigi Pinnarelli; Paola Castald ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 413 KB

## Abstract ## BACKGROUND. An insular growth pattern may be observed focally both in papillary and follicular thyroid carcinoma. The aim of the current study was to determine whether a greater extension of the insular component (IC) influences different clinical and histologic features at diagnosi

Deletion ofPTEN in a patient with Bannay
Deletion ofPTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease
โœ Arch, E. M.; Goodman, B. K.; Wesep, R.A. Van; Liaw, D.; Clarke, K.; Parsons, R.; ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 31 KB ๐Ÿ‘ 2 views

We report on an 18-month-old boy with an interstitial deletion at 10q23.2-q24.1. This region includes the PTEN gene, mutations of which have been reported to cause Cowden disease. Our patient presented with manifestations of Bannayan-Riley-Ruvalcaba (BRR) syndrome. The BRR syndrome is a rare disorde