โ Scribed by Girard, Eric ;Legrand, Pierre ;Roudenko, Olga ;Roussier, Lucile ;Gourhant, Patrick ;Gibelin, Jonathan ;Dalle, Didier ;Ounsy, Majid ;Thompson, Andrew William ;Svensson, Olof ;Cordier, Marie-Odile ;Robin, Sophie ;Quiniou, Rene ;Steyer, Jean-Philippe
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X-ray diffraction is an extremely important tool for structure determination of biological macromolecules, to the extent that currently around 85% of Protein Data Bank entries result from X-ray measurements. Many of these structure determinations use synchrotron radiation for data collection. This article aims to give synchrotron users an overview of the functioning of a synchrotron beamline and how the performance of various instruments combines to allow the collection of diffraction data.
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This manuscript chronicles the evolution of software used originally to control a diffractometer at a macromolecular crystallography beamline. The system has been augmented and rewritten. A modular and carefully organized suite of programs now handles the whole experimental environment from a single
A new strategy is presented to reduce primary X-ray damage in macromolecular crystallography. The strategy is based on separating the diffracting and damaged regions as much as feasible. The source of the radiation damage to macromolecular crystals is from two primary mechanisms: the direct excitati