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Insights into the Solution Structure of Human Deoxyhemoglobin in the Absence and Presence of an Allosteric Effector †

✍ Scribed by Sahu, Sarata C.; Simplaceanu, Virgil; Gong, Qingguo; Ho, Nancy T.; Tian, Fang; Prestegard, James H.; Ho, Chien


Book ID
127237945
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
218 KB
Volume
46
Category
Article
ISSN
0006-2960

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## Abstract Zinc ions have been shown to inhibit human immunodeficiency virus type 1 (HIV‐1) protease __in vitro__ at neutral pH [Zhang et al. __Biochemistry__, 36, 8717 (1991)]. Kinetic data from this study support a reversible binding mechanism of zinc in the active site. Preliminary calculations