Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1

Structural modeling and biochemical stud

Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of β-2-microglobulin by antibody BBM.1

✍ Jiamu Du; Hui Yang; Baozhen Peng; Jianping Ding 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB

## Abstract Human __β__‐2‐microglobulin (__β__2m) is the light chain of human leucocyte antigen‐I (HLA‐I). It can disassociate from HLA‐I and accumulate to cause serious dialysis‐related amyloidosis (DRA) in long‐term hemodialysis patients. Monoclonal antibody (mAb) BBM.1 can recognize both free‐fo