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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

✍ Scribed by Isaac Westwood; Donna-Marie Cheary; Joanne E. Baxter; Mark W. Richards; Rob L.M. van Montfort; Andrew M. Fry; Richard Bayliss


Book ID
116663982
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
686 KB
Volume
386
Category
Article
ISSN
0022-2836

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## Abstract Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical class