Insights into Receptor Function and New Drug Development Targets (Research and Perspectives in Endocrine Interactions)

✍ Scribed by M Conn, C Kordon & Y Christen (Eds.)

• Publisher: Springer
• Year: 2006
• Tongue: English
• Leaves: 211
• Edition: 1
• Category: Library

✦ Synopsis

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

✦ Table of Contents

Cover......Page 1
Series Title Page......Page 2
Inside Cover......Page 3
Copyright......Page 4
Introduction......Page 5
Table of Contents......Page 7
List of Contributors......Page 9
Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE......Page 16
Functional Rescue of Misfolded Receptor Mutants......Page 38
Obesity-relatedmutations of leptin and melanocortin receptors......Page 49
cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management......Page 66
Central Neuropeptide Receptors Involved inWater Balance: Application to Apelin......Page 91
Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity......Page 105
Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?......Page 116
Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists......Page 127
Mutations in G proteins and G protein-coupled receptors in human endocrine diseases......Page 149
A molecular dissection of the glycoprotein hormone receptors......Page 161
Receptor Tyrosine Kinases as Targets for Cancer Therapy Development......Page 177
Targets for pituitary tumor therapy......Page 189
The endogenous cannabinoid system in the control of food intake and energy balance......Page 198
Subject Index......Page 210