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Insights into peptide and protein function: a convergent approach

✍ Scribed by Bernard P. Roques

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
576 KB
Volume
7
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

From viruses to multicellular organisms, life is inseparable from the genetic instructions aimed at regulating its maintenance, division, multiplication, differentiation and death (apoptosis). Over the past 15 years, structural studies have begun to resolve the complex reactions involved in these fundamental processes in biology. The three‐dimensional representations of the complexes formed with peptides and/or proteins have allowed interpretation of the biochemical data and formulation of novel hypotheses about the control and execution of these processes. Moreover, they have opened the way to rational approaches for designing compounds able to interfere with these crucial events in normal or pathological conditions. Various results obtained in our laboratory in these fields are briefly summarized in this review. Copyright Β© 2001 European Peptide Society and John Wiley & Sons, Ltd.

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