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Insight into the Binding Mode for Cyclopentapeptide Antagonists of the CXCR4 Receptor

✍ Scribed by Jon Våbenø; Gregory V. Nikiforovich; Garland R. Marshall


Book ID
111368302
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
407 KB
Volume
67
Category
Article
ISSN
1747-0277

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## Abstract The chemokine receptor CXCR4 possesses multiple critical functions in normal and pathologic physiology. CXCR4 is a G‐protein‐coupled receptor that transduces signals of its endogenous ligand, the chemokine CXCL12 (stromal cell‐derived factor‐1, SDF‐1). The interaction between CXCL12 and