Inside Cover: Unnatural Polyketide Analogues Selectively Target the HER Signaling Pathway in Human Breast Cancer Cells (ChemBioChem 4/2010)

✍ Scribed by Seok Joon Kwon; Moon Il Kim; Bosung Ku; Lydie Coulombel; Jin-Hwan Kim; Joseph H. Shawky; Robert J. Linhardt; Jonathan S. Dordick

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 480 KB
• Volume: 11
• Category: Article
• ISSN: 1439-4227
• DOI: 10.1002/cbic.201090011

✦ Synopsis

The inside cover picture shows the inhibition of multiple HER receptors by unnatural polyketide analogues synthesized by using in vitro precursor-directed chalcone synthase (CHS) catalysis. For further information on how the inhibition of multiple HER receptors has the potential to improve anticancer therapy by intensifying the inhibition of subsequent cellular signaling pathways (e.g., PI3K/Akt signal pathway) see the Full Paper by J. Dordick and co-workers on p. 573 ff.