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Inside Cover: Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives (ChemMedChem 11/2010)

✍ Scribed by Prof. Oriana Tabarrini; Dr. Serena Massari; Dr. Dirk Daelemans; Dr. Francesco Meschini; Dr. Giuseppe Manfroni; Dr. Laura Bottega; Prof. Barbara Gatto; Prof. Manlio Palumbo; Prof. Christophe Pannecouque; Prof. Violetta Cecchetti

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 529 KB
Volume: 5
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.201090050

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Studies of Anti-HIV Transcription Inhibi

Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives

✍ Prof. Oriana Tabarrini; Dr. Serena Massari; Dr. Dirk Daelemans; Dr. Francesco Me 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB 👁 1 views

## Abstract __The 6‐desfluoroquinolones (6‐DFQs) are anti‐HIV agents that target Tat‐mediated transcription. This particular mechanism of action makes this class of compounds very attractive for further structural investigations. Identification of the pharmacophore required for inhibition will ulti