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Inside Cover: Structure of the Complex of [Ru(tpm)(dppz)py]2+ with a B-DNA Oligonucleotide—A Single-Substituent Binding Switch for a Metallo-Intercalator (Chem. Eur. J. 8/2010)

✍ Scribed by Philip Waywell; Veronica Gonzalez; Martin R. Gill; Harry Adams; Anthony J. H. M. Meijer; Mike P. Williamson; James A. Thomas

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 357 KB
Volume: 16
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.201090029

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✦ Synopsis

The NMR-derived structure of an achiral…

] complex bound to duplex DNA confirms that it intercalates from the minor groove as described in the Full Paper by J. A. Thomas et al. on page 2407 ff. The structure also explains why the nature and position of a single functional group acts as an on/off switch for intercalative binding and DNA light-switching effects.

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Structure of the Complex of [Ru(tpm)(dpp

Structure of the Complex of [Ru(tpm)(dppz)py]2+ with a B-DNA Oligonucleotide—A Single-Substituent Binding Switch for a Metallo-Intercalator

✍ Philip Waywell; Veronica Gonzalez; Martin R. Gill; Harry Adams; Anthony J. H. M. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 790 KB

## Abstract We report the synthesis of three new complexes related to the achiral [Ru(tpm)(dppz)py]^2+^ cation (tpm=tripyridazole methane, dppz=dipyrido[3,2‐__a__:2′,3′‐__c__]phenazine, py=pyridine) that contain an additional single functional group on the monodentate ancillary pyridyl ligand. Comp