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Inside Cover: Site-Specific DNA-Controlled Fusion of Single Lipid Vesicles to Supported Lipid Bilayers (ChemPhysChem 5/2010)

✍ Scribed by Lisa Simonsson; Peter Jönsson; Gudrun Stengel; Fredrik Höök

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 638 KB
Volume: 11
Category: Article
ISSN: 1439-4235
DOI: 10.1002/cphc.201090022

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✦ Synopsis

Site-specific DNA-programmed single-vesicle fusion to a supported lipid bilayer is demonstrated by F. Hççk et al. on p. 1011. Cholesterol-modified DNA zippers are used to constitute a reduced model system of the SNARE-protein complex controlling synaptic vesicle fusion.

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Site-Specific DNA-Controlled Fusion of Single Lipid Vesicles to Supported Lipid Bilayers

✍ Lisa Simonsson; Peter Jönsson; Gudrun Stengel; Fredrik Höök 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 558 KB

## Abstract __We investigate the Ca^2+^‐triggered fusion of lipid vesicles site‐selectively tethered to a DNA‐modified supported lipid bilayer array, with the DNA strands designed such that hybridization occurs in a zipperlike fashion. Prior to the addition of Ca^2+^, which is observed to induce do