Inside Cover: Photoactive RuII–Polypyridyl Complexes that Display Sequence Selectivity and High-Affinity Binding to Duplex DNA through Groove Binding (Chem. Eur. J. 7/2011)

✍ Scribed by Amrita Ghosh; Priyadip Das; Martin R. Gill; Prasenjit Kar; Michael G. Walker; Dr. Jim A. Thomas; Dr. Amitava Das

• Book ID: 101840185
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 458 KB
• Volume: 17
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.201190030

✦ Synopsis

2 , poly(dA)-poly(dT), and poly(dG)-poly(dC) has been observed for Ru II -polypyridyl complexes with a pendant catechol functionality. The Ru II -polypyridyl complexes preferentially bind to more flexible, alternating purine-pyrimidine sequences, particularly those that contain AT.TA steps, with very high affinities (K b > 10 7 m À1 ). For more details, see the Full Paper by J. A. Thomas, A.