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Inside Cover: Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers (Angew. Chem. Int. Ed. 14/2007)

✍ Scribed by Laurent Griffe; Mary Poupot; Patrice Marchand; Alexandrine Maraval; Cédric-Olivier Turrin; Olivier Rolland; Pascal Métivier; Gérard Bacquet; Jean-Jacques Fournié; Anne-Marie Caminade; Rémy Poupot; Jean-Pierre Majoral

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
35 KB
Volume
46
Category
Article
ISSN
0044-8249

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✦ Synopsis

Human peripheral blood mononuclear cells (white blood cells) cultured in the presence of dendrimers capped with phosphonate groups reveal a selective multiplication of natural killer (NK) cells. In their Communication on page 2523 ff., A.‐M. Caminade, R. Poupot, J.‐P. Majoral, and co‐workers describe the synthesis of various phosphazene dendrimers and their effect on NK cells, which play a key role in anticancer immunity. The picture shows a fluorescence microscopy image of a NK cell (red) engaged with target cancer cells (green).

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Contributed equally to this work. [\*\*] We thank Rhodia (grants to L.G., P.M., and O.R.), the CNRS (grant to A.M.), the EC (F.S.E. grant to M.P.), and the RØgion Midi-PyrØnØes ("Biotherapy" program) for financial support. We also thank Dr. Yannick Coppel for NMR spectra. Supporting information fo