Inside Cover: Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes (ChemMedChem 4/2010)

✍ Scribed by Claudia Pessoa; Paulo Michel P. Ferreira; Letícia Veras C. Lotufo; Manoel O. de Moraes; Suellen M. T. Cavalcanti; Lucas Cunha D. Coêlho; Marcelo Z. Hernandes; Ana Cristina L. Leite; Carlos A. De Simone; Vlaudia M. A. Costa; Valdênia M. O. Souza

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 430 KB
• Volume: 5
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.201090011

✦ Synopsis

The inside cover picture shows the design concept behind the antitumor and immunomodulatory phthalimides bio-inspired by thalidomide (top). Their immunosuppressor activity is derived from their ability to maintain low IL-10 production and suppress NO, with the advantage of not affecting the immune response elicited by T-lymphocytes. Phthalimide 2 b (bottom) is as strongly active against solid sarcoma as thalidomide. For more details, see the Communication by A. C. L. Leite et al. on p. 523 ff.