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Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010)

✍ Scribed by Sabine Klüter ; Dr. Jeffrey R. Simard ; Dr. Haridas B. Rode; Dr. Christian Grütter; Dr. Vijaykumar Pawar; Dr. Hans C. A. Raaijmakers; Dr. Tjeerd A. Barf; Dr. Matthias Rabiller; Prof. Dr. Willem A. L. van Otterlo ; Dr. Daniel Rauh

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 643 KB
Volume: 11
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201090088

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Characterization of Irreversible Kinase

Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance

✍ Sabine Klüter ; Dr. Jeffrey R. Simard ; Dr. Haridas B. Rode; Dr. Christian Grütt 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 702 KB

## Abstract Targeting protein kinases in cancer therapy with irreversible small‐molecule inhibitors is moving to the forefront of kinase‐inhibitor research and is thought to be an effective means of overcoming mutation‐associated drug resistance in epidermal growth factor receptor kinase (EGFR). We