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Insertion of a foreign gene into the β-casein locus by Cre-mediated site-specific recombination

✍ Scribed by Andreas F. Kolb; Ray Ansell; Jim McWhir; Stuart G. Siddell

Book ID: 117523486
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 755 KB
Volume: 227
Category: Article
ISSN: 0378-1119
DOI: 10.1016/s0378-1119(98)00607-6

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## Abstract To dissect the tissue‐specific functions of atrial natriuretic peptide (ANP), we recently introduced loxP sites into the murine gene for its receptor, guanylyl cyclase‐A (GC‐A), by homologous recombination (tri‐lox __GC‐A__). For either smooth‐muscle or cardiomyocyte‐restricted deletion