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Inotropic effects of endothelin in ferret ventricular myocardium

✍ Scribed by Ajay M. Shah; Malcolm J. Lewis; Andrew H. Henderson

Book ID
115882247
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
224 KB
Volume
163
Category
Article
ISSN
0014-2999

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Pharmacological characteristics of endot
Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium: The nonselective endothelin receptor antagonist PD 145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1
✍ Ikuo Norota; Masao Endoh πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 754 KB

Endothelin-3 (ET-3) elicited a concentration-dependent positive inotropic effect on rabbit papillary muscle, the maximal response being approximately 65% of the maximal response to isoproterenol. ET-1 induced a positive inotropic effect over the concentration range below 10(-9) M, at which ET-3 did