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Inostamycin, an inhibitor of cytidine 5′-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): Inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line

✍ Scribed by Yuh Baba; Mamoru Tsukuda; Izumi Mochimatsu; Shigeru Furukawa; Hiroko Kagata; Yoji Nagashima; Naoki Sakai; Shinri Koshika; Masaya Imoto; Yasumasa Kato

Book ID: 110241389
Publisher: Springer
Year: 2000
Tongue: English
Weight: 154 KB
Volume: 18
Category: Article
ISSN: 0262-0898
DOI: 10.1023/a:1006798900743

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✍ Yuh Baba; Mamoru Tsukuda; Izumi Mochimatsu; Shigeru Furukawa; Hiroko Kagata; Yoj 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 206 KB

Inostamycin, which was recently isolated from Streptomyces sp. MH816-AF15 as an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small cell lung carcinomas. To investigate whether the cytostatic effect of