𝔖 Bobbio Scriptorium
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Inositol may worsin attention deficit disorder with hyperactivity

✍ Scribed by Joseph Levine; Aliza Ring; Yoram Barak; Avner Elizur; R. H. Belmaker

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
286 KB
Volume
10
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Antidepressant drugs have been reported to improve ADDH symtomatology. Myoinositol is a simple isomer of glucose and is the precursor of the phosphatidylinositol second messenger system in brain. Both Ξ±~1~‐adrenergic and 5HT~2~ receptors activate this second messenger system. Recently, we found inositol to be effective in depression. Therefore we decided to evaluate the effects of oral inositol in children with ADDH in a double‐blind, cross‐over, placebo‐controlled manner. Eleven children, mean age 8.9 Β± 3.6 years with a mean illness duration of 4.5 Β± 2.8 years were enrolled in an 8‐week trial. Inositol or dextrose (placebo) was dispensed in powder form at a dose of 200 mg/kg aggravation of the syndrome with myo‐inositol as compared to placebo.

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