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Inositol hexaphosphate–loaded red blood cells prevent in vitro sickling

✍ Scribed by Vanessa Bourgeaux; Olivier Hequet; Yannick Campion; Gaëlle Delcambre; Anne-Marie Chevrier; Dominique Rigal; Yann Godfrin

Book ID
109145977
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
655 KB
Volume
50
Category
Article
ISSN
0372-1248

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In vitro exposure to hydroxyurea reduces
In vitro exposure to hydroxyurea reduces sickle red blood cell deformability
✍ Zhi Huang; Joseph G. Louderback; S. Bruce King; Samir K. Ballas; Daniel B. Kim-S 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB 👁 2 views

## Abstract Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal eryth