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Inositol 1,4,5-trisphosphate receptors, secretory granules and secretion in endocrine and neuroendocrine cells

✍ Scribed by Olivier Blondel; Graeme I. Bell; Susumu Seino

Book ID
116103966
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
649 KB
Volume
18
Category
Article
ISSN
0166-2236

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## Abstract Inositol 1,4,5‐trisphosphate receptors (IP~3~R) are ligand‐gated intracellular Ca^2+^channels that mediate release of Ca^2+^ from intracellular stores into the cytosol on activation by second messenger IP~3~. Similarly, IP~3~R mediated changes in cytosolic Ca^2+^ concentrations control