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Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

✍ Scribed by Ross, Christopher A.; Meldolesi, Jacopo; Milner, Teresa A.; Satoh, Tomohide; Supattapone, Surachai; H. Snyder, Solomon

Book ID: 109759107
Publisher: Nature Publishing Group
Year: 1989
Tongue: English
Weight: 468 KB
Volume: 339
Category: Article
ISSN: 0028-0836
DOI: 10.1038/339468a0

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## Abstract Inositol 1,4,5‐trisphosphate receptors (IP~3~R) are ligand‐gated intracellular Ca^2+^channels that mediate release of Ca^2+^ from intracellular stores into the cytosol on activation by second messenger IP~3~. Similarly, IP~3~R mediated changes in cytosolic Ca^2+^ concentrations control