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Inosine 5′-monophosphate dehydrogenase from Sarcoma 180 cells—Substrate and inhibitor specificity

✍ Scribed by Richard L. Miller; David L. Adamczyk


Book ID
115773115
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
737 KB
Volume
25
Category
Article
ISSN
0006-2952

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## Abstract Inosine 5‐monophosphate dehydrogenase II, a key enzyme in the __de novo__ synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor