Antiproliferative effects of AVN944, a n
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Daniel Floryk; Timothy C. Thompson
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Article
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2008
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John Wiley and Sons
🌐
French
⚖ 384 KB
## Abstract Inosine 5‐monophosphate dehydrogenase II, a key enzyme in the __de novo__ synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor