Innovative approaches to the use of polyamines for DNA nanoparticle preparation for gene therapy
✍ Scribed by Vijayanathan, Veena; Agostinelli, Enzo; Thomas, Thresia; Thomas, T. J.
- Book ID
- 120571291
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 474 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract High molecular weight chitosan (CS) was depolymerized by oxidative degradation with NaNO~2~ at room temperature to get 11 samples of CS derivatives of varying molecular weights with a view to assessing their effective molecular weight range for gene delivery applications. Viscosity stud
The objective of this work was to obtain a nanoparticle formulation that could be sterile filtered, lyophilized, and resuspended to the initial size with excipients appropriate for use as a vaccine formulation. Poly(lactide-co-glycolide) (PLG) polymers were used to create nanoparticles ranging in si